6202-22-8
- Product Name：MITRAGYNINE
- Molecular Formula：C23H30N2O4
- Purity：99%
- Molecular Weight：398.502
Product Details;
CasNo： 6202-22-8
Molecular Formula： C23H30N2O4
Buy High Quality MITRAGYNINE, Factory Sells 6202-22-8 Safe Shipping
- Molecular Formula:C23H30N2O4
- Molecular Weight:398.502
- Vapor Pressure:1.39E-12mmHg at 25°C
- Boiling Point:560.3°Cat760mmHg
- Flash Point:292.7°C
- Density:1.22g/cm3
MITRAGYNINE(Cas 6202-22-8) Usage
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General Description |
Mitragynine is an indole-based alkaloid, abundantly present in the Southeast Asian plant Mitragyna speciosa, commonly known as kratom. With a concentration ranging from 0.5 to 1.5% in dried leaves, mitragynine has been identified as a partial opioid agonist, acting on µ (MOR), δ (DOR), and κ (KOR) receptors. It produces stimulant effects in low doses and sedative effects in high doses. First isolated in 1921, its chemical structure was fully elucidated in 1964. |
| Uses | Known for its analgesic properties, mitragynine's action on opioid receptors makes it comparable to morphine. It has garnered interest for potential medicinal uses, including treating opioid withdrawal and chronic pain. However, its dual stimulant-sedative nature and the associated risks of dependence and addiction have led to ongoing debates about its safety and efficacy. Consequently, legal status and regulation of mitragynine vary widely across different countries and regions. |
InChI:InChI=1/C23H30N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h6-8,13-14,16,19,24H,5,9-12H2,1-4H3/b17-13+/t14-,16+,19+/m1/s1
6202-22-8 Relevant articles
MITRAGYNINE ANALOGS FOR THE TREATMENT OF PAIN, MOOD DISORDERS AND SUBSTANCE USE DISORDERS
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Page/Page column 54; 60; 70, (2020/03/05)
The present invention provides a compoun...
Mitragynine ‘Kratom’ Related Fatality: A Case Report with Postmortem Concentrations
Iain M. McIntyre, Amber Trochta, Susan Stolberg, Steven C. Campman
Journal of Analytical Toxicology, Volume 39, Issue 2, March 2015, Pages 152–155
We describe a death attributed to mixed drug toxicity—primarily mitragynine. The current report revealed the detection of mitragynine by routine toxicology screening, describes a specific gas chromatography–mass spectrometry selective ion mode (GC–MS SIM) analysis and presents the postmortem concentrations in peripheral blood, central blood, liver, vitreous, urine and gastric contents.
Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators
Kruegel, Andrew C.,Gassaway, Madalee M.,Kapoor, Abhijeet,Váradi, András,Majumdar, Susruta,Filizola, Marta,Javitch, Jonathan A.,Sames, Dalibor
, p. 6754 - 6764 (2016/06/14)
Mu-opioid receptor agonists represent ma...
6202-22-8 Process route
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C25H34N2O6
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- 4098-40-2,4697-67-0,14382-79-7,14509-92-3,6202-22-8
mitragynine
| Conditions | Yield |
|---|---|
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With sodium tris(acetoxy)borohydride; acetic acid; In methanol; at 20 - 90 ℃; Inert atmosphere; Reflux;
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100% |
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C22H27N2O4(1-)*Na(1+)
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- 77-78-1
dimethyl sulfate
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![methyl (Z)-2-((2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate](/upload/2024/1/c98ce837-39e5-4098-9fdc-f8cf26df9b8e.png)
- 6202-22-8
methyl (Z)-2-((2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate
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- 4098-40-2,4697-67-0,14382-79-7,14509-92-3,6202-22-8
mitragynine
| Conditions | Yield |
|---|---|
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In benzene; at 20 ℃; for 20h;
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27% 31% |
6202-22-8 Upstream products
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173102-63-1
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918430-83-8
C25H34N2O6
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951327-94-9
(2R,3S,12bS)-tert-butyl 3-ethyl-8-methoxy-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7-hexahydroindolo[2,3-a]quinolizine-12(12bH)-carboxylate
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107-31-3
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6202-22-8 Downstream products
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methyl (E)-2-((2S,3S,12bS)-3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate
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