117772-70-0
- Product Name：Azithromycin dihydrate
- Molecular Formula：C38H72N2O12.2H2O
- Purity：99%
- Molecular Weight：767.011
Product Details;
CasNo： 117772-70-0
Molecular Formula： C38H72N2O12.2H2O
Appearance： White or almost white crystalline powder
Chinese Factory Supply 117772-70-0 with Efficient Shipping, Offer Azithromycin dihydrate
- Molecular Formula:C38H72N2O12*H2O
- Molecular Weight:767.011
- Appearance/Colour:White or almost white crystalline powder
- Vapor Pressure:2.51E-31mmHg at 25°C
- Melting Point:126 °C
- Refractive Index:-47 ° (C=2, EtOH)
- Boiling Point:822.1 °C at 760 mmHg
- Flash Point:451 °C
- PSA：198.54000
- Density:1.18 g/cm3
- LogP:1.71000
Azithromycin dihydrate (Cas 117772-70-0) Usage
Azithromycin dihydrate is a medication commonly prescribed to treat various bacterial infections, including bronchitis, pneumonia, sexually transmitted diseases (STDs), and infections affecting the ears, lungs, sinuses, skin, throat, and reproductive organs. It is administered in the form of white crystalline powder. ZITHROMAX tablets, which contain azithromycin dihydrate, provide 600 mg of azithromycin per dose. The recommended dosage is usually once a day, taken at the same time daily, with tablets and capsules swallowed whole with water. Azithromycin capsules should be taken either at least 1 hour before or 2 hours after meals. Peak concentrations of the medication are achieved between two and a half to just over three hours after administration. A loading dose may be employed to reach steady concentrations more quickly. The medication can be dosed once daily, and it may take several days for symptoms of infection to subside.
117772-70-0 Relevant articles
A PROCESS FOR PREPARING 9-DEOXO-9A-AZA-9A-HOMOERYTHROMYCIN A
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Page/Page column 11, (2008/06/13)
The invention relates to a process for p...
Stability and thermophysical properties of azithromycin dihydrate
S. Timoumi b, D. Mangin a, R. Peczalski a, F. Zagrouba b, J. Andrieu a
, Arabian Journal of Chemistry Volume 7, Issue 2, April 2014, Pages 189-195
The aim of this paper was to describe the temperature effect on the stability and the thermophysical properties of azithromycin (AZ). First, the density, the heat capacity and the solubility of original (commercial) AZ were determined. Second, the original samples were heated at 50 °C and 80 °C and their PLM, DSC, TGA and XRD data were compared to those of the original AZ.
PROCESS FOR PREPARING NON-HYGROSCOPIC AZITHROMYCIN DIHYDRATE
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Page 7, (2008/06/13)
A direct, single step process for prepar...
On the solid state conformation of azithromycin monohydrate and dihydrate pseudopolymorphs
José Manuel Montejo-Bernardo , Santiago Garcia-Granda , Miguel Santos Bayod-Jasanada , Lujan Llavona-Díaz and Isidro Llorente
, Zeitschrift für Kristallographie - Crystalline Materials, September 25, 2009
This paper describes the crystal structure of the azithromycin monohydrate pseudopolymorph (pseudopolymorphic forms, different solvates of the same chemical compound, azithromycin in our case) crystallised from isopropanol, solved by X-ray single crystal, and called isopropanol clathrate monohydrate (Apotex, US 6,245,903).
117772-70-0 Process route
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- 50-00-0,30525-89-4,61233-19-0
formaldehyd
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- 76801-85-9
9-Deoxo-9a-aza-9a-homoerythromycin A
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- 117772-70-0,121470-24-4
azithromycin dihydrate
| Conditions | Yield |
|---|---|
|
formaldehyd; 9-Deoxo-9a-aza-9a-homoerythromycin A; With formic acid; In acetone; at 40 - 45 ℃; for 7 - 8h;
With sodium hydroxide; In water; acetone; pH=11 - 11.5;
With water; In acetone; at 20 ℃; for 24h;
|
87% |
|
formaldehyd; 9-Deoxo-9a-aza-9a-homoerythromycin A; With formic acid; In water; acetone; at 20 - 55 ℃; for 8h;
With water; In acetone; at 38 - 40 ℃; for 10 - 12h;
With water;
|
76.7% |
|
formaldehyd; 9-Deoxo-9a-aza-9a-homoerythromycin A; With formic acid; In chloroform; water; at 20 - 55 ℃; for 10 - 20h; Heating / reflux;
With water; In acetone; at 38 - 40 ℃; for 10 - 12h;
|
73% |
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- 117772-70-0,121470-24-4
azithromycin dihydrate
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- 117772-70-0,121470-24-4
azithromycin Monohydrate
| Conditions | Yield |
|---|---|
|
In acetic acid methyl ester; at 20 - 60 ℃;
|
|
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With sodium sulfate; In acetone; for 0.166667h;
|
|
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azithromycin dihydrate; With hydrogenchloride; In water;
With sodium hydroxide; In water; at 20 - 55 ℃; for 0.5h; pH=10 - 11;
|
|
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In ethanol; at 20 ℃; for 1h;
|
117772-70-0 Upstream products
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117772-70-0
azithromycin dihydrate
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83905-01-5
Zithromax(R)
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7732-18-5
water
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76801-85-9
9-Deoxo-9a-aza-9a-homoerythromycin A
117772-70-0 Downstream products
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117772-70-0
azithromycin Monohydrate
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