330936-70-4
- Product Name：(GLY14)-HUMANIN (HUMAN)
- Molecular Formula：C118H202 N34 O31 S2
- Purity：99%
- Molecular Weight：2657.21
Product Details;
CasNo： 330936-70-4
Molecular Formula： C118H202 N34 O31 S2
Quality Manufacturer Supply (GLY14)-HUMANIN (HUMAN) ,Export 330936-70-4 Low Price
- Molecular Formula:C118H202 N34 O31 S2
- Molecular Weight:2657.21
(GLY14)-HUMANIN (HUMAN)(Cas 330936-70-4) Usage
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Description |
(Gly14)-Humanin (human) is an analog of the endogenous peptide Humanin, where the 14th amino acid serine is replaced with glycine. Also referred to as (Gly14)-Humanin (human) or 14-Glycine-Humanin (human) acetate, it exhibits enhanced neuroprotective properties compared to Humanin. |
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Uses |
This analog is remarkably more potent, being 1,000 times more active than the original Humanin. With a peptide purity of 98.2%, (Gly14)-Humanin represents a promising and highly purified neuroprotective factor with potential therapeutic applications. |
330936-70-4 Relevant articles
[Gly14]-humanin exerts a protective effect against D-galactose-induced primary ovarian insufficiency in mice
Jin Huang 1, Qiwen Feng 1, Liping Zou, Yumeng Liu, Meng Bao, Wei Xia
, Reproductive BioMedicine Online Volume 48, Issue 2, February 2024, 103330
D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model. Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks. Ovarian morphology, function, levels of sex hormones and states of oxidative stress in the ovary and body were evaluated.
Protective effects of [Gly14]-Humanin on β-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction
Hui Jin a, Tao Liu a, Wei-Xi Wang a, Jie-Hua Xu a, Peng-Bo Yang b, Hai-Xia Lu b, Qin-Ru Sun a, Hai-Tao Hu a
, Neurochemistry International Volume 56, Issue 3, February 2010, Pages 417-423
Humanin (HN) and its derivative, [Gly14]-Humanin (HNG), are known for their ability to suppress neuronal death induced by AD-related insults in vitro and in vivo. In the present study, we investigated the neuroprotective effects of HNG on Aβ25–35-induced toxicity and its potential mechanisms in PC12 cells.
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