611-75-6

Description

Bromhexine Hydrochloride is the hydrochloride salt form of bromhexine, characterized as a secretolytic agent with mucolytic activity. It operates by enhancing lysosomal activity, promoting the hydrolysis of acid mucopolysaccharide polymers in the respiratory tract. This process increases the production of serous mucus, leading to thinner phlegm and reduced mucus viscosity. The secretomotoric effect of bromhexine allows cilia to more efficiently transport phlegm out of the lungs. This mechanism is beneficial in treating respiratory disorders associated with abnormal viscid mucus, excessive mucus secretion, and impaired mucus transport.

Chemical Properties

White Solid

Originator

Bisolvon,Boehringer Ingelheim,Switz.,1963

Uses

Respiratory Disorders: Bromhexine hydrochloride is employed for its therapeutic effects in respiratory conditions characterized by abnormal, thick mucus. It aids in clearing mucus from the respiratory tract.

Pancreatic Juice Secretion: Historically, bromhexine hydrochloride has been utilized in the secretion of pancreatic juice with low viscosity.

Definition

ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of bromhexine and hydrogen chloride. It is used as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of spu um).

Manufacturing Process

In initial steps, 2-nitrobenzylbromide and cyclohexylmethylamine are reacted and that initial product reacted with hydrazine to give N-(2-aminobenzyl)-Nmethyl- cyclohexylamine. A solution of 29.3 g of bromine in 50 cc of glacial acetic acid was slowly added dropwise to a solution of 159 g of N-(2-aminobenzyl)-N-methylcyclohexylamine, accompanied by stirring. The glacial acetic acid was decanted from the precipitate formed during the addition of the bromine solution, and the precipitate was thereafter shaken with 200 cc of 2N sodium hydroxide and 600cc of chloroform until all of the solids went into solution. The chloroform phase was allowed to separate from the aqueous phase. The chloroform phase was decanted, evaporated to dryness and the residue was dissolved in absolute ether. The resulting solution was found to be a solution of N-(2-amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine in ethanol. Upon introducing hydrogen chloride into this solution, the hydrochloride of N-(2- amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine precipitated out. It had a melting point of 232°-235°C (decomposition).

Therapeutic Function

Expectorant; Mucolytic

General Description

Bromhexine hydrochloride is a bronchial mucolytic.