What is the 3-Hydroxy-4-methoxycinnamic acid?

3-Hydroxy-4-methoxycinnamic acid is Off-white crystalline solid, while it's Molecular Formula is C10H10O4. Off-white crystalline solid 3-Hydroxy-4-methoxycinnamic acid was used in the synthesis of tranilast and various tranilast analogs (cinnamoyl anthranilates) by genetically engineered Saccharomyces cerevisiae yeast strain. It was also used in the synthesis of glycoside compounds by undergoing glycosidation.

What is the CAS number for 3-Hydroxy-4-methoxycinnamic acid?

The CAS number of 3-Hydroxy-4-methoxycinnamic acid is 537-73-5.

What is the 3-Hydroxy-4-methoxycinnamic acid?

3-Hydroxy-4-methoxycinnamic acid is Off-white crystalline solid, while it's Molecular Formula is C10H10O4. Off-white crystalline solid 3-Hydroxy-4-methoxycinnamic acid was used in the synthesis of tranilast and various tranilast analogs (cinnamoyl anthranilates) by genetically engineered Saccharomyces cerevisiae yeast strain. It was also used in the synthesis of glycoside compounds by undergoing glycosidation.

What is the CAS number for 3-Hydroxy-4-methoxycinnamic acid?

The CAS number of 3-Hydroxy-4-methoxycinnamic acid is 537-73-5.

Product classification

537-73-5

Product Name：3-Hydroxy-4-methoxycinnamic acid
Molecular Formula：C₁₀H₁₀O₄
Purity：99%
Molecular Weight：194.187

Inquiry

Product Details;

CasNo： 537-73-5

Molecular Formula： C₁₀H₁₀O₄

Appearance： Off-white crystalline solid

Chinese Manufacturer Supply High Purity 99% 3-Hydroxy-4-methoxycinnamic acid 537-73-5 with Best Price

Molecular Formula:C10H10O4
Molecular Weight:194.187
Appearance/Colour:Off-white crystalline solid
Vapor Pressure:1.83E-07mmHg at 25°C
Melting Point:230 °C (dec.)(lit.)
Refractive Index:1.5168 (estimate)
Boiling Point:410.2 °C at 760 mmHg
PKA:4.53±0.10(Predicted)
Flash Point:167.6 °C
PSA：66.76000
Density:1.316 g/cm³
LogP:1.49860

3-Hydroxy-4-methoxycinnamic acid(Cas 537-73-5) Usage

Chemical Properties	Off-White Crystalline Solid
Uses	3-Hydroxy-4-methoxycinnamic acid serves as an efficient acetylcholine inhibitor and is a bioactive metabolite of Spilanthes acmella Murr. It plays a role in increasing the resistance of low-density lipoprotein (LDL) to oxidation. Beyond its natural occurrence, 3-Hydroxy-4-methoxycinnamic acid is recognized for its antidiabetic activity. It is found in various organisms, including Sibiraea angustata, Astragalus onobrychis, black cohosh, and Ipomoea aquatica leaves. This compound showcases potential therapeutic properties, particularly in the context of managing diabetes and oxidative stress.
Definition	ChEBI: A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 4 and 3 respectively on the phenyl ring.
General Description	3-Hydroxy-4-methoxycinnamic acid, commonly known as Isoferulic acid, is a hypoglycemic agent available in the form of white crystals. It is isolated from the aerial part of Artemisia capillaris, a Chinese medicinal plant.

InChI:InChI=1/C10H10O4/c1-14-9-4-2-7(6-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/p-1/b5-3+

537-73-5 Relevant articles

Insulin-Releasing Properties of a Series of Cinnamic Acid Derivatives in Vitro and in Vivo

S Adisakwattana, P Moonsan

, J. Agric. Food Chem. 2008, 56, 17, 7838–7844

For example, isoferulic acid (3-hydroxy-4-methoxycinnamic acid) exhibits significantly decreased levels of plasma glucose concentration in streptozotocin (STZ)-induced diabetic rats by …

Isoferuloyl derivatives of five seed glucosinolates in the crucifer genus Barbarea

Agerbirk, Niels,Olsen, Carl Erik

, p. 610 - 623 (2011)

Five acylated glucosinolates (GSLs) were...

Regioselectivity of Cobalamin-Dependent Methyltransferase Can Be Tuned by Reaction Conditions and Substrate

Pompei, Simona,Grimm, Christopher,Farnberger, Judith E.,Schober, Lukas,Kroutil, Wolfgang

, p. 5977 - 5983 (2020/10/06)

Regioselective reactions represent a sig...

Copper and L-(?)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air

Bao, Xuefei,Chen, Guoliang,Dong, Jinhua,Du, Fangyu,Li, Hui,Liang, Xinjie,Wu, Ying,Zhang, Yongsheng

supporting information, (2020/08/03)

L-(?)-Quebrachitol, a natural product ob...

Structural features and antioxidant activities of Chinese quince (Chaenomeles sinensis) fruits lignin during auto-catalyzed ethanol organosolv pretreatment

Cheng, Xi-Chuang,Guo, Xin-Ran,Liu, Hua-Min,Liu, Yu-Lan,Qin, Zhao,Wang, Xue-De

, p. 4348 - 4358 (2020/09/22)

Chinese quince fruits (Chaenomeles sinen...

537-73-5 Process route

: 621-59-0
isovanillin

: 141-82-2
malonic acid

: 537-73-5
trans-3-hydroxy-4-methoxycinnamic acid

Conditions

Conditions	Yield
With piperidine; pyridine; for 3h; Heating;	94%
With piperidine; pyridine; In ethanol; for 3h; Heating;	92%
With pyridine; acetic acid; at 130 ℃; for 0.333333h; microwave irradiation;	86%
With N,N-dimethyl acetamide; triethylamine; N,N-dimethyl-formamide; In toluene; for 4h; Reflux;	85%
With piperidine; pyridine; In toluene; at 110 ℃; for 12h; Dean-Stark;	78.4%
With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; for 4h; Reflux; Inert atmosphere;	77.2%
With piperidine; pyridine; at 120 ℃; for 4h;	58%
With piperidine; pyridine; for 3.5h; Heating;	52%
With piperidine; pyridine;
With piperidine; In pyridine;
In pyridine; for 3h; Heating;
With piperidine; pyridine; at 90 ℃;
isovanillin; malonic acid; With piperidine; pyridine; at 120 ℃; for 6h; With hydrogenchloride; In water; pH=3;
With piperidine; In pyridine; at 120 ℃; for 1.5h;
With pyridine; at 90 ℃;
With pyridine; aniline; In toluene; at 95 ℃;

: 103261-25-2
3-iodo-4-methoxy-trans-cinnamic acid

: 537-73-5
trans-3-hydroxy-4-methoxycinnamic acid