PT-141 is white powder, while it's Molecular Formula is C50H68N14O10. white powder Treatment of sexual dysfunction (melanocortin receptor agonist).Bremelanotide is used to treat low sexual desire in women who have not gone through menopause and have not had low sexual desire in the past.bremelanotide should be used only to treat low sexual desire that occurs with any type of sexual activity, in any sexual situation, or with any sexual partner.Bremelanotide should not be used to treat low sexual desire that is caused by relationship problems, health problems, mental illness, or by using certain drugs or medications.https://www.drugs.com

Product classification

189691-06-3

Q: What is PT-141 (189691-06-3) used for?

Bremelanotide (Vyleesi?) was approved by the FDA in June 2019 for the treatment of acquired, generalized HSDD in premenopausal women. Bremelanotide activates melanocortin receptors，but the mechanism by which it improves sexual desire is unknown. To use bremelanotide, women inject it under the skin ofthe abdomen or thigh at least 45 minutes before anticipated sexual activity.The optimal time to inject bremelanotide may vary based on the duration of benefit and side effects experienced. More than one dose of bremelanotide should not be used within 24 hours or more than eight doses per month. Common side effects include nausea, vomiting, flushing, injection site reactions, and headache. Bremelanotide should not be used in women with high blood pressure that is uncontrolled or in those with known cardiovascular disease, and it is not recommended for women at high risk for cardiovascular disease. The safety and efficacy of bremelanotide has not been studied in breast cancer survivors, and there are no recommendations regarding its use in this population.InChI:InChI=1/C50H68N14O10/c1-3-4-16-35(58-29(2)65)43(67)64-41-25-42(66)54-20-11-10-18-37(49(73)74)60-46(70)39(23-31-26-56-34-17-9-8-15-33(31)34)62-44(68)36(19-12-21-55-50(51)52)59-45(69)38(22-30-13-6-5-7-14-30)61-47(71)40(63-48(41)72)24-32-27-53-28-57-32/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25H2,1-2H3,(H,53,57)(H,54,66)(H,58,65)(H,59,69)(H,60,70)(H,61,71)(H,62,68)(H,63,72)(H,64,67)(H,73,74)(H4,51,52,55)/t35-,36-,37-,38+,39-,40-,41?/m0/s1

Product Name：Bremelanotide
Molecular Formula：C₅₀H₆₈N₁₄O₁₀
Purity：99%
Molecular Weight：1025.18

Inquiry

Product Details;

CasNo： 189691-06-3

Molecular Formula： C₅₀H₆₈N₁₄O₁₀

Appearance： white powder

Quality products make an important contribution to long-term revenue and profitability.

1.What is the PT-141 ?

PT-141, also known as Bremelanotide, is a melanocortin agonist primarily utilized for the treatment of sexual dysfunction, particularly erectile dysfunction (ED) in men and hypoactive sexual desire disorder (HSDD) in women. It acts as a synthetic peptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH), targeting melanocortin receptors to stimulate sexual arousal and desire.

: 189691-06-3
bremelanotide

: diethyl 4-((3r,5r,7r)-adamantan-1-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

: C₆₀H₈₂N₁₄O₁₀

Conditions

Conditions	Yield
With trifluoroacetic acid; In 2,2,2-trifluoroethanol; at 35 ℃; for 9h; chemospecific reaction; Irradiation; Inert atmosphere; Sealed tube;	47%

: 189691-06-3
bremelanotide

: 1539-59-9
4-cyclohexyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

: C₅₆H₇₈N₁₄O₁₀

Conditions

Conditions	Yield
With trifluoroacetic acid; In 2,2,2-trifluoroethanol; at 35 ℃; for 9h; chemospecific reaction; Irradiation; Inert atmosphere; Sealed tube;	38%

2.What is the CAS number for PT-141 ?

The CAS number of PT-141 is 189691-06-3.

3.What are another words for PT-141 ?

Synonyms for PT-141 189691-06-3:N-Acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysine (2-7)-lactam;Bremelanotide;PT 141;

4.What is the molecular formula of PT-141?

The chemical formula of PT-141 is C50H68N14O10 which containing 50 Carbon atoms,68 Hydrogen atoms,14 Nitrogen atoms and 10 Oxygen atoms,and the molecular weight of PT-141 is 1025.18.

5.What is PT-141 (189691-06-3) used for?

Clinical trials have demonstrated the efficacy of PT-141 in inducing erectile response in both healthy male subjects and ED patients. PT-141 has also shown promise in addressing HSDD in women. This disorder is characterized by a lack or absence of sexual fantasies or desire for sexual activity in the absence of a diagnosed psychological disorder or relationship issues. By stimulating sexual arousal and desire pathways, PT-141 may help alleviate symptoms of HSDD in affected women.

Relevant articles related to PT-141:

Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction

A maximum-tolerated dose was not identified. Flushing and nausea were the most common adverse events reported in both studies and no clinically significant changes in vital signs, laboratory tests, ECGs, or physical exams were observed. Based upon its erectogenic potential and tolerability profile, PT-141 is a promising candidate for further evaluation as a treatment for male ED.

, International Journal of Impotence Research volume 16, pages51–59 (2004)

AT-Home Efficacy of an Intranasally Administered Melanocortin Receptor Agonist, PT-141, In Men with Erectile Dysfunction (ED)

Melanocortin receptors in the central nervous system play a role in important behaviors including sexual arousal and body weight regulation. PT -141, a peptide analog of alpha-melanocyte-stimulating hormone, induces erections in normal men and those with ED. We evaluated the safety and efficacy of intranasally (IN) administered PT -14lfor the treatment of male ED in the at-home environment.

, THE JOURNAL OF UROLOGY, Vol. 171, No. 4

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