Product classification

144701-48-4

Q: What is the Telmisartan?

Telmisartan is White or off white crystalline powder, while it's Molecular Formula is C33H30N4O2. White or off white crystalline powder Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart

Q: What is Telmisartan (144701-48-4) used for?

Telmisartan was launched in the US for the treatment of hypertension.It can be prepared in eight steps starting with methyl 4-amino-3-methylbenzoate; the first and second cyclization into a benzimidazole ring occur atsteps 4 and 6 respectively. Telmisartan blocks the action of angiotensin II (AngII), the primary effector molecule of the renin-angiotensin-aldosterone system(RAAS). It is the sixth of this class of 《sartans》 to be marketed after the leadcompound Losartan. Its long lasting effect (24h half-life) could be the maindifference with other angiotensin II antagonists. Unlike several other agents inthis category, its activity does not depend upon transformation into an activemetabolite, the 1-O-acylglucuronide being the principal metabolite found inhumans. Telmisartan is a potent competitive antagonist of AT1 receptors that mediate most of the important effects of angiotensin II while lacking affinity forthe AT2 subtypes or other receptors involved in cardiovascular regulation. Inseveral clinical studies, Telmisartan, at a once daily dosage, produced effectiveand sustained blood-pressure lowering effects with a low incidence of sideeffects (particularly treatment-related cough associated with ACE inhibitors inelderly patients).InChI:InChI=1/C33H30N4O2/c1-7-12-33-39-34-24(2)21-27(35-38-30-15-10-11-16-31(30)40(35)6)22-32(34)41(33)23-25-17-19-26(20-18-25)28-13-8-9-14-29(28)36(42)43-37(3,4)5/h8-11,13-22H,7,12,23H2,1-6H3

Product Name：Telmisartan
Molecular Formula：C₃₃H₃₀N₄O₂
Purity：99%
Molecular Weight：514.627

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Product Details;

CasNo： 144701-48-4

Molecular Formula： C₃₃H₃₀N₄O₂

Appearance： White or off white crystalline powder

We supply high quality Telmisartan (CAS 144701-48-4), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the Telmisartan ?

Telmisartan is an angiotensin II receptor blocker (ARB) medication used to treat conditions such as high blood pressure (hypertension), heart failure, and diabetic kidney disease. It functions by blocking the action of angiotensin II, a substance that causes blood vessels to constrict, thereby relaxing blood vessels, lowering blood pressure, and improving blood flow to the heart.

What is the CAS number for Telmisartan ?

The CAS number of Telmisartan is 144701-48-4.

What is Telmisartan (144701-48-4) used for?

Telmisartan is primarily prescribed to manage high blood pressure, a condition that increases the workload on the heart and arteries, potentially leading to cardiovascular complications if left untreated. By blocking angiotensin II receptors, telmisartan helps to lower blood pressure and reduce the risk of associated health problems. In individuals with heart failure, telmisartan may be used as part of the treatment regimen to improve heart function and reduce symptoms such as shortness of breath and fatigue. By promoting vasodilation and increasing blood flow to the heart, telmisartan can help alleviate the strain on the heart muscle. Clinical trials have demonstrated that telmisartan is as effective as other major classes of antihypertensive agents in lowering blood pressure. Additionally, compared to certain other antihypertensive medications like lisinopril, telmisartan is associated with a lower incidence of side effects such as dry, persistent cough, making it a preferred option for some patients.

Articles related to Telmisartan:

Article

Source

Effect of Telmisartan on Renal Outcomes

No important difference was found in the composite renal outcome with telmisartan (58 patients [1.96%]) versus placebo (46 patients [1.55%]) (hazard ratio, 1.29 [95% CI, 0.87 to 1.89]; P = 0.20). Among the telmisartan and placebo groups, 7 and 10 patients had dialysis and 56 and 36 patients had doubling of serum creatinine, respectively (hazard ratio, 1.59 [CI, 1.04 to 2.41]; P = 0.031).

, Annals of Internal Medicine, 7 July 2009

Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events

In patients who have vascular disease or high-risk diabetes without heart failure, angiotensin-converting–enzyme (ACE) inhibitors reduce mortality and morbidity from cardiovascular causes, but the role of angiotensin-receptor blockers (ARBs) in such patients is unknown. We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes.

, N Engl J Med 2008; 358:1547-1559

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