402856-42-2
- Product Name：Tesofensine
- Molecular Formula：C17H23NCl2O
- Purity：99%
- Molecular Weight：0
Product Details;
CasNo： 402856-42-2
Molecular Formula： C17H23NCl2O
Best Quality Chinese Factory Supply Tesofensine 402856-42-2 In Bulk Supply. We supply high quality Tesofensine (CAS 402856-42-2), in stock, factory directly supply to clients, lower prices, more competitiveness.
What is the Tesofensine ?
Tesofensine is , while it's Molecular Formula is C17H23NCl2O. Tesofensine, is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity.
What is the CAS number for Tesofensine ?
The CAS number of Tesofensine is 402856-42-2.
More information of Tesofensine 402856-42-2 are:
|
Synonyms |
Tesofensine |
|
CAS Number |
402856-42-2 |
|
Molecular Formula |
C17H23NCl2O |
|
Molecular Weight |
0 |
|
Density |
1.162 g/cm3 |
|
Boiling Point |
396.629 °C at 760 mmHg |
|
Flash Point |
193.675 °C |
|
PSA |
12.47000 |
|
LogP |
4.53410 |
What is Tesofensine (402856-42-2) used for?
InChI:InChI=1/C17H23Cl2NO/c1-3-21-10-14-13(9-12-5-7-17(14)20(12)2)11-4-6-15(18)16(19)8-11/h4,6,8,12-14,17H,3,5,7,9-10H2,1-2H3/t12?,13-,14-,17?/m1/s1
Articles related to Tesofensine:
| Tesofensine, a Novel Triple Monoamine Reuptake Inhibitor, Induces Appetite Suppression by Indirect Stimulation of α1 Adrenoceptor and Dopamine D1 Receptor Pathways in the Diet-Induced Obese Rat |
Using an automatized food intake monitoring system during a 12 h nocturnal test period, tesofensine-induced hypophagia was investigated further by studying the acute interaction of a variety of monoamine receptor antagonists with tesofensine-induced hypophagia in the DIO rat. Tesofensine (0.5–3.0 mg/kg, s.c.) induced a dose-dependent and marked decline in food intake with an ED50 of 1.3 mg/kg. , Neuropsychopharmacology volume 35, pages1464–1476 (2010) |
| Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial |
161 (79%) participants completed the study. After 24 weeks, the mean weight loss produced by diet and placebo was 2·0% (SE 0·60). Tesofensine 0·25 mg, 0·5 mg, and 1·0 mg and diet induced a mean weight loss of 4·5% (0·87), 9·2% (0·91), and 10·6% (0·84), respectively, greater than diet and placebo (p<0·0001). , The Lancet, VOLUME 372, ISSUE 9653, P1906-1913, NOVEMBER 29, 2008 |
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