864070-44-0
- Product Name：Empagliflozin
- Molecular Formula：C23H27ClO7
- Purity：99%
- Molecular Weight：450.916
Product Details;
CasNo： 864070-44-0
Molecular Formula： C23H27ClO7
Factory Sells Chinese Factory Supply Empagliflozin 864070-44-0 Cheapest Price
- Molecular Formula:C23H27ClO7
- Molecular Weight:450.916
- Boiling Point:665℃
- PKA:13.23±0.70(Predicted)
- Flash Point:356℃
- PSA：108.61000
- Density:1.398
- LogP:1.61340
864070-44-0 Relevant articles
Synthetic method of empagliflozin
-
Paragraph 0039; 0041-0042; 0044, (2021/10/30)
The invention discloses a synthesis meth...
Synthesis, Isolation, Characterization and Suppression of Impurities during Optimization of Empagliflozin (Jardiance)
Liu, Xiao,Peng, Peng,Yang, Jiangtao,Yu, Jun,Zhang, Fuli,Zhao, Chuanmeng
, (2022/03/14)
-
Synthetic method of empagliflozin
-
, (2021/07/24)
The invention belongs to the technical f...
Preparation method of SGLT-2 inhibitor and intermediate
-
Paragraph 0112-0118, (2021/05/19)
The invention discloses a preparation me...
864070-44-0 Process route
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-
C51H49ClO7
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-
864070-44-0,1620758-33-9,864070-43-9
empagliflozin
| Conditions | Yield |
|---|---|
|
With
hydrogen;
In
ethanol;
at 75 - 80 ℃;
for 20h;
under 6000.6 - 6750.68 Torr;
Solvent;
Inert atmosphere;
Autoclave;
|
93.7% |
-
-
864070-37-1
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
-
-
219823-47-9
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
-
-
864070-44-0,1620758-33-9,864070-43-9
empagliflozin
| Conditions | Yield |
|---|---|
|
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 75 ℃;
for 21h;
|
57% |
|
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 75 ℃;
for 18h;
|
49% |
|
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 75 ℃;
for 18h;
|
49% |
|
With
caesium carbonate;
at 25 - 40 ℃;
|
|
|
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 30 - 45 ℃;
for 24h;
|
0.55 kg |
864070-44-0 Upstream products
-
864070-37-1
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
-
219823-47-9
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
-
915095-96-4
methyl-1-C-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucopyranoside
-
1279691-36-9
(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
864070-44-0 Downstream products
-
915095-99-7
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-trityl triacetate
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